Open Access<p>Deficiency of <em>PTEN</em> and <em>CDKN2A</em> Tumor-Suppressor Genes in Conventional and Chondroid Chordomas: Molecular Characteristics and Clinical Relevance</p>
Author(s) -
Chenlong Yang,
Jianjun Sun,
Yong Lei,
Liang Chen,
Shipeng Li,
Yulun Xu,
Jun Yang,
Xiaoguang Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s252990
Subject(s) - pten , cdkn2a , suppressor , cancer research , gene , microbiology and biotechnology , medicine , biology , genetics , apoptosis , pi3k/akt/mtor pathway
Chordoma is a malignant tumor predominantly involving the skull base and vertebral column. This study aimed to investigate the molecular characteristics of PTEN and CDKN2A in conventional and chondroid chordomas and their correlation with clinical prognosis.