Open Access<p>TDO Promotes Hepatocellular Carcinoma Progression</p>
Author(s) -
Shanbao Li,
Lei Li,
Junyi Wu,
Fangbin Song,
Zhiwei Qin,
Lei Hou,
Chao Xiao,
Junyong Weng,
Xuebin Qin,
Jianrong Xu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s252929
Subject(s) - hepatocellular carcinoma , cancer research , biomarker , in vivo , metastasis , medicine , kynurenine , phenotype , limiting , carcinoma , cancer , biology , gene , tryptophan , biochemistry , engineering , mechanical engineering , microbiology and biotechnology , amino acid
Tryptophan 2,3-dioxygenase (TDO), encoded by the gene TDO2, is an enzyme that catalyses the first and rate-limiting step of tryptophan (Try) degradation in the kynurenine (Kyn) pathway in the liver. Recently, TDO has been demonstrated to be expressed in various human tumours, especially hepatocellular carcinoma (HCC). However, the role of TDO in HCC is still not very clear. Here, we studied the role of TDO in HCC.