Open Access<p>miR-519d-3p Overexpression Inhibits P38 and PI3K/AKT Pathway via Targeting VEGFA to Attenuate the Malignant Biological Behavior of Non-Small Cell Lung Cancer</p>
Author(s) -
Guangzhao Zhang,
Yanlei Hu,
Wei Yuan,
Hongli Qiu,
Haifeng Yu,
Jiahui Du
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s252795
Subject(s) - cancer research , in vivo , apoptosis , flow cytometry , pi3k/akt/mtor pathway , protein kinase b , cell growth , microrna , oncogene , chemistry , western blot , biology , cell cycle , microbiology and biotechnology , biochemistry , gene
Non-small cell lung cancer (NSCLC) is a heterogeneous tumor that accounts for approximately 85% of all lung cancer cases worldwide. microRNAs (miRNAs) are believed to play an important role in regulating a variety of biological processes, including immunity and cancer. We investigated the effect of miR-519d-3p on the mitigation of NSCLC in vitro and in vivo.