Open Access<p>LncRNA XIST Promotes Growth of Human Chordoma Cells by Regulating miR-124-3p/iASPP Pathway</p>
Author(s) -
Hai Bai,
Xiaoyu Pan,
Chuanchao Du,
Tianli Mao,
FuJun Jia,
Yü Liu,
Yunlong Ma,
Xiaoguang Liu,
Bin Zhu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s252195
Subject(s) - xist , gene silencing , long non coding rna , biology , cancer research , downregulation and upregulation , rna interference , cell growth , microbiology and biotechnology , rna , x inactivation , gene , genetics , x chromosome
Chordoma is a malignant primary bone tumor that is found in the spine and skull. X-inactive specific transcript (XIST) is a long non-coding RNA (lncRNA) is known to be involved in the development of various cancers, but its precise function and mechanism in human chordoma have not been elucidated. Here, we investigated the role of lncRNA XIST in chordoma progression.