Open Access<p>MicroRNA-3666 Suppresses Cell Growth in Head and Neck Squamous Cell Carcinoma Through Inhibition of PFKFB3-Mediated Warburg Effect</p>
Author(s) -
Lan Chen,
Yaxuan Cao,
Bei Wu,
Yu Cao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s251992
Subject(s) - head and neck squamous cell carcinoma , cancer research , cell growth , warburg effect , microrna , anaerobic glycolysis , cell , glycolysis , biology , chemistry , cancer , biochemistry , metabolism , head and neck cancer , genetics , gene
MicroRNA-3666 (miR-3666) is aberrantly expressed and plays critical roles in numerous human tumors. However, the expression pattern, biological role, and mechanisms of action of miR-3666 in head and neck squamous cell carcinoma (HNSCC) remain unknown. Therefore, we attempted to determine the expression status and function of miR-3666 in HNSCC and to explore the underlying mechanisms in detail.