Open Access<p>TP53INP2 Modulates Epithelial-to-Mesenchymal Transition via the GSK-3β/β-Catenin/Snail1 Pathway in Bladder Cancer Cells</p>
Author(s) -
Zhengtao Zhou,
Xiaoqiang Liu,
Yulei Li,
Junhua Li,
Wen Deng,
Jian Zhong,
Luyao Chen,
Li Yu,
XianTao Zeng,
Gongxian Wang,
Jingyu Zhu,
Bin Fu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s251830
Subject(s) - epithelial–mesenchymal transition , bladder cancer , gene knockdown , gene silencing , cancer research , gsk 3 , downregulation and upregulation , catenin , cancer cell , cancer , chemistry , transfection , autophagy , signal transduction , medicine , biology , wnt signaling pathway , metastasis , microbiology and biotechnology , cell culture , apoptosis , biochemistry , genetics , gene
The tumor protein p53-inducible nuclear protein 2 (TP53INP2), an autophagy protein, is essential for autophagosome formation. The deregulation of autophagy is associated with multiple human diseases, including cancer. The present study aims to explore the role of TP53INP2 in bladder cancer.