Open AccessInhibition of ERKs/Akt-Mediated c-Fos Expression Is Required for Piperlongumine-Induced Cyclin D1 Downregulation and Tumor Suppression in Colorectal Cancer Cells
Author(s) -
Feng Gao,
Liqun Zhou,
Ming Li,
Wenbin Liu,
Shuting Yang,
Wei Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s251295
Subject(s) - cyclin d1 , protein kinase b , cancer research , carcinogenesis , cell cycle , pi3k/akt/mtor pathway , downregulation and upregulation , cyclin , chemistry , cyclin d3 , biology , cancer , microbiology and biotechnology , signal transduction , cell , biochemistry , gene , genetics
Deregulation of Cyclin D1 and cell cycle progression plays a critical role in tumorigenesis. The natural compound piperlongumine (PL) exhibits potential anticancer effects in various cancer models, but the underlying mechanism needs further elucidation.