Open Access<p>Histamine H3 Receptor Promotes Cell Survival via Regulating PKA/CREB/CDKN1A Signal Pathway in Hepatocellular Carcinoma</p>
Author(s) -
Chunle Zhang,
Yang Yu,
Liang Ma,
Ping Fu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s250655
Subject(s) - creb , cell growth , cancer research , cell cycle , apoptosis , downregulation and upregulation , flow cytometry , signal transduction , cell , viability assay , biology , microbiology and biotechnology , transcription factor , gene , biochemistry , genetics
The histamine H3 receptor (HRH3) is mainly expressed in areas of the brain involved in the regulation of the release of various neurotransmitters. Recent studies have shown that HRH3 expression is increased in several types of carcinomas. However, the functional roles and underlying molecular mechanism by which HRH3 regulates cell survival in hepatocellular carcinoma (HCC) remain unknown.