Open Access<p>CTHRC1 in Ovarian Cancer Promotes M2-Like Polarization of Tumor-Associated Macrophages via Regulation of the STAT6 Signaling Pathway</p>
Author(s) -
Yi-Han Bai,
Kemin Yin,
Tong Su,
Fang Ji,
Shu Zhang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s250520
Subject(s) - cd163 , cancer research , macrophage polarization , m2 macrophage , cd68 , tumor microenvironment , ovarian cancer , tumor associated macrophage , gene knockdown , metastasis , stat6 , cell migration , chemistry , western blot , cell , immunohistochemistry , interleukin 4 , biology , cell culture , medicine , immunology , macrophage , cancer , cytokine , in vitro , genetics , biochemistry , tumor cells , gene
The infiltration of tumor-associated macrophages (TAMs) facilitates the progression of epithelial ovarian cancer (EOC). TAMs are mainly M2-like due to exposure to various factors in the tumor microenvironment. In our previous study, we reported that collagen triple helix repeat containing 1(CTHRC1), a secreted protein, is associated with ovarian cancer progression and metastasis. However, the correlation between CTHRC1 and the immunological microenvironment in EOC remains unknown.