Open Access<p>MicroRNA-623 Inhibits Epithelial–Mesenchymal Transition to Attenuate Glioma Proliferation by Targeting TRIM44</p>
Author(s) -
Dawei Cui,
Kaijie Wang,
Yan Liu,
Junling Gao,
Jianzhong Cui
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s250497
Subject(s) - cancer research , gene knockdown , microrna , glioma , cell growth , epithelial–mesenchymal transition , metastasis , cancer , biology , western blot , cell culture , medicine , gene , biochemistry , genetics
Glioma has the highest incidence among the different tumor types within the nervous system, accounting for about 40% of them. Malignant glioma has a high invasion and metastasis rate, which leads to the poor prognosis of patients. By targeting specific genes, microRNAs serve as key regulators in the epithelial-mesenchymal transformation (EMT) process, which could provide new insights into the treatment of glioblastomas (GBM). The detailed molecular role that miR-623 plays in GBM still remains unclear.