Open Access<p>Knockdown of circ_0000512 Inhibits Cell Proliferation and Promotes Apoptosis in Colorectal Cancer by Regulating miR-296-5p/RUNX1 Axis</p>
Author(s) -
Lihong Wang,
Huili Wu,
Feifei Chu,
Li Zhang,
Xia Xiao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s250495
Subject(s) - gene knockdown , viability assay , cell growth , apoptosis , flow cytometry , cell cycle , cancer research , chemistry , microbiology and biotechnology , microrna , cyclin d1 , biology , gene , biochemistry
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Increasing evidence showed that circular RNAs (circRNAs) played critical roles in the progression of CRC. However, the effects and underlying mechanisms of circ_0000512 in CRC progression remain unclear.