Open Access<p>HOPX Is an Epigenetically Inactivated Tumor Suppressor and Overexpression of HOPX Induce Apoptosis and Cell Cycle Arrest in Breast Cancer</p>
Author(s) -
Qinghua You,
Yuanyuan Geng,
Huiying Ye,
Gui-Xiang Zhu,
Xiaofang Gao,
Hongbo Zhu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s250404
Subject(s) - bisulfite sequencing , dna methylation , cancer research , breast cancer , methylation , cyclin d1 , cancer , cell cycle , gene silencing , biology , downregulation and upregulation , apoptosis , microbiology and biotechnology , medicine , gene expression , gene , genetics
Evidence has been shown that abnormal DNA methylation plays a vital role in the progression of breast cancer via silencing of gene expression. The results of bisulfite sequencing showed that the methylation status of HOPX in breast cancer tissues was higher than that in normal breast cancer tissues, but little known about the biological functions of HOPX in breast cancer.