Open Access<p>Expression Level of Wnt5a Was Related to the Therapeutic Effects of First-Generation EGFR-TKIs</p>
Author(s) -
Hai Zhang,
Xiaohua Yang,
Fang Hu,
Changhui Li,
Jianlin Xu,
Wei Nie,
Yao Shen,
YuQing Lou,
Baohui Han,
Hua Zhong,
Xueyan Zhang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s250024
Subject(s) - immunohistochemistry , medicine , lung cancer , adenocarcinoma , staining , epidermal growth factor receptor , cancer research , therapeutic effect , oncology , cancer , pathology
The first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have shown significant therapeutic effects on patients harboring sensitive EGFR mutations, while the mechanisms related to drug resistance have still remained elusive. This study aimed to indicate the relationship between the expression level of Wnt5a with therapeutic effects of first-generation EGFR-TKIs on lung adenocarcinoma patients harboring sensitive EGFR mutations.