Open Access<p>Rapamycin Reduces Cervical Cancer Cells Viability in Hypoxic Condition: Investigation of the Role of Autophagy and Apoptosis</p>
Author(s) -
Davood Rezazadeh,
Amir Hossein Norooznezhad,
Kamran Mansouri,
Mozhgan Jahani,
Ali Mostafaie,
Mohammad Hossein Mohammadi,
Mohammad Hossein Modarressi
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s249985
Subject(s) - autophagy , hela , acridine orange , propidium iodide , apoptosis , programmed cell death , viability assay , cancer research , cancer cell , pi3k/akt/mtor pathway , cell growth , cell , chemistry , biology , medicine , cancer , biochemistry
Rapamycin has been known as an anti-cancer agent that affects different malignancies such as glioblastoma and prostate cancer. However, there are few studies concerning rapamycin effects on the cervical cancer cells. In this study, it was aimed to investigate the possible effect of rapamycin on a cervical cancer cell line and explored the possible mechanism(s) and pathway(s) for this agent.