Open Access<p>Long Noncoding RNA CAR10 Contributes to Melanoma Progression By Suppressing miR-125b-5p to Induce RAB3D Expression</p>
Author(s) -
Jing Xie,
Yanyan Zheng,
Xiaomin Xu,
Congcong Sun,
Mingfen Lv
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s249736
Subject(s) - melanoma , gene knockdown , downregulation and upregulation , cancer research , long non coding rna , gene silencing , cell growth , tumor progression , metastasis , cell culture , medicine , in vivo , cancer , biology , gene , genetics
Melanoma is a very malignant skin cancer with high mortality and unsatisfactory prognosis. Many long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in melanoma. How lncRNA regulates melanoma progression is poorly defined. LncRNA CAR10 has been shown to regulate the progression of several cancers and its role in melanoma remains unclear. This study aims to determine the role and mechanism of lncRNA CAR10 in the regulation of melanoma progression.