Open Access<p>Rat Bone Marrow-Derived Mesenchymal Stem Cells Promote the Migration and Invasion of Colorectal Cancer Stem Cells</p>
Author(s) -
Weiyan Zou,
Jie Zhao,
Yang Li,
Zishu Wang,
Hai-Qin Yan,
Yudong Liu,
Meiqun Sun,
Jialu Zhuang,
Junbin Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s249353
Subject(s) - cd44 , cancer stem cell , mesenchymal stem cell , cancer research , stem cell , colorectal cancer , flow cytometry , bone marrow , metastasis , cancer cell , pathology , cancer , biology , chemistry , medicine , cell , immunology , microbiology and biotechnology , genetics
Colorectal cancer is one of the most common cancers and the second leading cause of cancer-related deaths worldwide. Targeting cancer stem cells (CSCs) may be a novel strategy for the treatment of colorectal cancer. Previous studies have shown that bone marrow-derived MSCs (BM-MSCs) promote tumor growth and metastasis. However, the role of rat BM-MSCs in the biological behaviors of colorectal CSCs remains unclear until now.