Open Access<p>miR-148a Regulates the Stem Cell-Like Side Populations Distribution by Affecting the Expression of ACVR1 in Esophageal Squamous Cell Carcinoma</p>
Author(s) -
Yao Tan,
Xi Lü,
Zhiyong Cheng,
Guangpeng Pan,
Shujuan Liu,
Palida Apiziaji,
Haifeng Wang,
Jinrong Zhang,
Yisikandaer Abulimiti
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s248925
Subject(s) - microrna , cancer research , klf4 , cell growth , flow cytometry , carcinogenesis , cancer stem cell , side population , chromatin immunoprecipitation , cell , stem cell , biology , population , cell cycle , cell migration , sox2 , cancer , microbiology and biotechnology , medicine , gene expression , gene , promoter , transcription factor , biochemistry , genetics , environmental health
Esophageal squamous cell carcinoma (ESCC) is a malignant tumor disease with high mortality and morbidity rates, especially for a terminal cancer. At present, the prognosis and treatment of ESCC cannot effectively control or inhibit the spread and proliferation of tumor cells. microRNAs, a class of small spliced RNAs, are essential in the regulation of tumorigenesis and tumor cell migration and proliferation. microRNAs interact with target mRNA to silence gene expression and degrade mRNA, thereby inhibiting the expression of tumor genes or impairing the expression of tumor suppressor genes.