Open Access<p>The miR-1224-5p/ELF3 Axis Regulates Malignant Behaviors of Pancreatic Cancer via PI3K/AKT/Notch Signaling Pathways</p>
Author(s) -
Lingming Kong,
Peng Liu,
Mingjun Zheng,
Zhongpeng Wang,
Yang Gao,
Keke Liang,
Huaitao Wang,
Xiaodong Tan
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s248507
Subject(s) - pancreatic cancer , cancer research , microrna , western blot , pi3k/akt/mtor pathway , protein kinase b , cancer , biology , notch signaling pathway , signal transduction , gene , microbiology and biotechnology , genetics
Aberrant expression of microRNAs contributes to the progression of pancreatic cancer by targeting downstream genes. A novel regulatory axis, miR-1224-5p/ELF3, was identified by bioinformatic analysis and experimental verification. Studies of the underlying molecular mechanisms behind this axis lead to a better understanding of the development of pancreatic cancer.