Open Access<p>Dihydroartemisinin Inhibits the Proliferation, Colony Formation and Induces Ferroptosis of Lung Cancer Cells by Inhibiting PRIM2/SLC7A11 Axis</p>
Author(s) -
Bing Yuan,
Feng Liao,
ZhiZhou Shi,
Yuan Ren,
Xiaoli Duan,
Tingting Yang,
Deng-Yuan Li,
Ru-Fang Li,
Dandan Pu,
Yujue Wang,
Yan Tan,
Zhen Yang,
Yunhui Zhang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s248492
Subject(s) - dihydroartemisinin , lung cancer , cell growth , cancer research , programmed cell death , trypan blue , viability assay , cancer cell , apoptosis , cancer , pharmacology , chemistry , biology , medicine , immunology , biochemistry , plasmodium falciparum , artemisinin , malaria
Lung cancer is the first leading cause of cancer-related deaths both worldwide and in China and threatens human health and quality of life. New drugs and therapeutic methods are urgently needed. Our study evaluated the roles of dihydroartemisinin (DHA) in lung cancer and further explored its underlying mechanisms.