Open Access<p>ADAMTS8 Inhibits Cell Proliferation and Invasion, and Induces Apoptosis in Breast Cancer</p>
Author(s) -
Kun Zhang,
Ruoxi Tian,
Guanglin Wang,
Jianfeng Zhang,
Hua Ma,
Xuhua Hu,
Jinchuan Xi,
Guiying Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s248085
Subject(s) - transfection , gene knockdown , cell growth , apoptosis , lipofectamine , flow cytometry , microbiology and biotechnology , cancer research , western blot , chemistry , gentamicin protection assay , mtt assay , cell culture , biology , gene , biochemistry , recombinant dna , genetics , vector (molecular biology)
A disintegrin and metallopeptidase with thrombospondin motifs (ADAMTSs), whose expression is dysregulated in various cancers, is implicated in cancer development. Herein, we aimed to investigate the functional role of ADAMTS8 in breast cancer (BC) and explore the underlying mechanisms.