Open Access<p>Advances and Prospects of Vasculogenic Mimicry in Glioma: A Potential New Therapeutic Target?</p>
Author(s) -
Heng Cai,
Wenjing Liu,
Xiaobai Liu,
Zhiqing Li,
Tianda Feng,
Yixue Xue,
Yunhui Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s247855
Subject(s) - vasculogenic mimicry , glioma , cancer research , medicine , mechanism (biology) , neuroscience , pathology , biology , cancer , metastasis , philosophy , epistemology
Vasculogenic mimicry (VM) is the formation of a "vessel-like" structure without endothelial cells. VM exists in vascular-dependent solid tumors and is a special blood supply source involved in the highly invasive tumor progression. VM is observed in a variety of human malignant tumors and is closely related to tumor proliferation, invasion, and recurrence. Here, we review the mechanism, related signaling pathways, and molecular regulation of VM in glioma and discuss current research problems and the potential future applications of VM in glioma treatment. This review may provide a new viewpoint for glioma therapy.