Open Access<p>MicroRNA-375 Targets ATG14 to Inhibit Autophagy and Sensitize Hepatocellular Carcinoma Cells to Sorafenib</p>
Author(s) -
Shuo Yang,
Minggang Wang,
Liang Yang,
Yan Li,
Yingbo Ma,
Xueqiang Peng,
Xinyu Li,
Bowen Li,
Hongyuan Jin,
Hangyu Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s247655
Subject(s) - sorafenib , autophagy , hepatocellular carcinoma , flow cytometry , cancer research , chemistry , viability assay , cell growth , apoptosis , microrna , microbiology and biotechnology , medicine , biology , biochemistry , gene
Sorafenib has revolutionized treatment of hepatocellular carcinoma (HCC), but its efficacy is limited by drug resistance. Autophagy is the process by which cellular components are transported to lysosomes for degradation, which promotes energy production and production of macromolecular precursors. Studies have suggested that the cytoprotective function of autophagy may contribute to chemoresistance or targeted drug resistance in cancer cells. We investigated the effects of miR-375 and autophagy-related protein 14, and their interrelationships, on sorafenib efficacy.