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HER2 overexpression has been identified in approximately 14% of bladder adenocarcinomas. However, until now, there has been no approved standard targeted therapy for bladder adenocarcinoma patients harboring HER2 genetic alteration.

oncotargets and therapy

&lt;p&gt;Response to Anti-HER2-Based Treatment in a Patient with Bladder Adenocarcinoma Harboring &lt;em&gt;HER2&lt;/em&gt; Amplification and S310F Mutation Discovered by Next-Generation Sequencing: A Case Report&lt;/p&gt;