Open Access<p>Novel Nanocomplexes Targeting STAT3 Demonstrate Promising Anti-Ovarian Cancer Effects in vivo</p>
Author(s) -
Xiaolei Zhang,
Tao Lü,
Yonggang Ma,
Rui Li,
Yingxin Pang,
Hongluan Mao,
Peishu Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s247398
Subject(s) - in vivo , decoy , ovarian cancer , stat3 , cancer research , apoptosis , cancer cell , survivin , cancer , chemistry , medicine , biology , biochemistry , receptor , microbiology and biotechnology
Cationic solid lipid nanoparticles (SLN) have attracted intensive interest as an effective gene delivery system for its high biocompatibility, stability and low cytotoxicity. In our previous study, we successfully prepared SLN-STAT3 decoy ODN complexes and made a primary study on its antitumor behavior in ovarian cancer cells in vitro. However, there is little information available so far about the effect of SLN-STAT3 decoy ODN complexes on ovarian cancer in vivo, either little information about the pharmacological toxicology in vivo.