Open Access<p>RSF-1 siRNA Enhances Tumor Radiosensitivity in Cervical Cancer via Enhanced DNA Damage, Cell Cycle Redistribution, and Promotion of Apoptosis</p>
Author(s) -
Jing Tian,
Enqi Kong,
Xiangyu Wang,
Zhaoguang Xie,
Cherry Yin-Yi Chang,
Jim JinnChyuan Sheu,
Hao Qin,
Li Sun
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s246632
Subject(s) - cell cycle , apoptosis , comet assay , hela , dna damage , cancer research , radiosensitivity , blot , viability assay , microbiology and biotechnology , cell , flow cytometry , cell cycle checkpoint , chemistry , cell growth , radiation sensitivity , biology , medicine , radiation therapy , dna , biochemistry , gene , nuclear physics , irradiation , physics
Remodeling and spacing factor-1 (RSF-1) is an identified tumor biomarker that is overexpressed in a variety of human cancers, but its effect on radiotherapy remains unclear. In this study, we aimed to explore the effect of RSF-1 siRNA on sensitizing cervical cancer cells to radiation and its underlying mechanism.