Open Access<p>Inhibition of EGFR Signaling and Activation of Mitochondrial Apoptosis Contribute to Tanshinone IIA-Mediated Tumor Suppression in Non-Small Cell Lung Cancer Cells</p>
Author(s) -
Feng Gao,
Ming Li,
Wenbin Liu,
Wei Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s246606
Subject(s) - cancer research , protein kinase b , chemistry , carcinogenesis , signal transduction , epidermal growth factor receptor , cell growth , downregulation and upregulation , viability assay , cancer , apoptosis , medicine , biochemistry , gene
Deregulation of epidermal growth factor receptor (EGFR) signaling plays a critical role in non-small cell lung cancer (NSCLC) tumorigenesis. The natural product Tanshinone IIA (Tan IIA) exhibits significant anti-tumor effect in various human cancers, however, the mechanism remains elusive.