Open Access<p>Crosstalk Between AR and Wnt Signaling Promotes Castration-Resistant Prostate Cancer Growth</p>
Author(s) -
Jun Luo,
Dan Wang,
Xuechao Wan,
Yunfeng Xu,
YuChuan Lu,
Zhe Kong,
Dujian Li,
Wei Gu,
Chenji Wang,
Yao Li,
Chaoneng Ji,
Shaohua Gu,
Yixiang Xu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s245861
Subject(s) - prostate cancer , crosstalk , wnt signaling pathway , medicine , cancer research , oncology , signal transduction , biology , cancer , microbiology and biotechnology , physics , optics
Prostate cancer (PCa) is the most commonly diagnosed cancer and the third leading cause of cancer-related death in males in the United States. Despite the initial efficacy of androgen deprivation therapy in prostate cancer (PCa) patients, most patients progress to castration-resistant prostate cancer. However, the mechanisms underlying the androgen-independent progression of PCa remain largely unknown.