Open Access<p>SRC Promotes Tamoxifen Resistance in Breast Cancer via Up-Regulating SIRT1</p>
Author(s) -
Jun Zhou,
Ming Xu,
Kehao Le,
Jie Ming,
Hui Guo,
Shengnan Ruan,
Tao Huang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s245749
Subject(s) - tamoxifen , breast cancer , proto oncogene tyrosine protein kinase src , medicine , cancer research , cancer , oncology , endocrinology , receptor
Endocrine therapy plays a key role in estrogen receptor-positive breast cancer patients; but, tamoxifen resistance could be a real difficulty for these patients. Several attempts have been made to explore the mechanism and new therapies for these patients. We intend to clarify the expression change of SRC and SIRT1 in tamoxifen-resistant breast cancer cells and explore their functions on tamoxifen resistance.