Open Access<p>Long Noncoding RNA H19 Facilitates Small Cell Lung Cancer Tumorigenesis Through miR-140-5p/FGF9 Axis</p>
Author(s) -
Xingkai Li,
Fang Lv,
Fang Li,
Minjun Du,
Yicheng Liang,
Shaolong Ju,
Zixu Liu,
Bing Wang,
Yushun Gao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s245710
Subject(s) - downregulation and upregulation , carcinogenesis , microrna , long non coding rna , cancer research , competing endogenous rna , lung cancer , cell growth , biology , cancer , western blot , medicine , pathology , gene , genetics
Long noncoding RNAs (lncRNAs) are emerging as gene regulators to drive many important cancer phenotypes through interaction with microRNAs. There have been numerous data about upregulation of H19 and its strong oncogenic function in progression of cancers. However, the function and detailed mechanisms of H19 on small cell lung cancer (SCLC) are still unclear.