Open Access<p>PIM3 Promotes the Proliferation and Migration of Acute Myeloid Leukemia Cells</p>
Author(s) -
Hongmei Luo,
Ruixue Sun,
Yuhuan Zheng,
Jingcao Huang,
Fangfang Wang,
Dan Long,
Yuzhang Wu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s245578
Subject(s) - myeloid leukemia , pim1 , flow cytometry , cell culture , cell growth , chemotaxis , phosphorylation , immunofluorescence , cancer research , leukemia , cxcr4 , blot , apoptosis , myeloid , western blot , biology , gene , microbiology and biotechnology , immunology , receptor , biochemistry , genetics , antibody , chemokine , inflammation , serine
Acute myeloid leukemia (AML) is associated with a poor overall prognosis. PIM family genes, including PIM1, PIM2 , and PIM3 , are proto-oncogenes that are aberrantly overexpressed in different types of human cancers. In this study, we aimed to explore and clarify the function of PIM3 in AML.