Open Access<p>miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer</p>
Author(s) -
You-Yi Huang,
Haixing Jiang,
Qiuyue Shi,
Xin Qiu,
Xi Wang,
Xianglian Zhang,
Shanyu Qin
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s245346
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , cancer research , kinase , ascites , rptor , hepatocyte growth factor , biology , signal transduction , chemistry , medicine , microbiology and biotechnology , receptor
Our previous experiments confirmed that T helper type 9 (Th9) cells were involved in the occurrence and development of malignant ascites caused by liver cancer. The current study investigated the mechanism underlying microRNA (miR-145)-mediated inhibition of Th9 cells in an malignant ascites model with liver cancer.