Open Access<p>Targeting eIF3f Suppresses the Growth of Prostate Cancer Cells by Inhibiting Akt Signaling</p>
Author(s) -
Junhong Li,
Wandong Yu,
Jianchao Ge,
Jun Zhang,
Yang Wang,
Pengyu Wang,
Guowei Shi
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s244345
Subject(s) - gene knockdown , protein kinase b , cell culture , in vivo , cell growth , small hairpin rna , rna interference , microbiology and biotechnology , in vitro , pi3k/akt/mtor pathway , signal transduction , cancer research , biology , rna , biochemistry , genetics , gene
Eukaryotic initiation factor 3 (eIF3) is the largest translation initiation factor, and oncogenic roles have been discovered for its subunits, including the f subunit (ie, eIF3f), in various human cancers. However, the roles of eIF3f in the development and progression of prostate cancer (PCa) have not been reported.