Open Access<p>GPR30 Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells via Activating the AKT and ERK Pathways</p>
Author(s) -
Binshan Zha,
Peng Qiu,
Chenxin Zhang,
Xinyuan Li,
Zhiyong Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s244128
Subject(s) - gper , vascular smooth muscle , blot , protein kinase b , phenotype , estrogen receptor , mapk/erk pathway , signal transduction , receptor , microbiology and biotechnology , cancer research , endocrinology , biology , medicine , smooth muscle , biochemistry , gene , cancer , breast cancer
Lower extremity varicose veins (LEVVs) are a common venous disorder of venous dilation and tortuosity. The functional integrity of vascular smooth muscle cells (VSMCs), the majority of the cells in venous tissues, and their phenotypic differences play important roles in the occurrence and development of LEVV. However, the underlying mechanism remains unclear.