Open Access<p>Low-Dose Radiation Promotes Invasion and Migration of A549 Cells by Activating the CXCL1/NF-κB Signaling Pathway</p>
Author(s) -
Jing Li,
Dongming Wu,
Rong Han,
Yan Yu,
Shihua Deng,
Teng Li,
Ting Zhang,
Ying Xu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s243914
Subject(s) - cxcl1 , a549 cell , gene knockdown , apoptosis , downregulation and upregulation , epithelial–mesenchymal transition , cell migration , flow cytometry , chemistry , signal transduction , cancer research , microbiology and biotechnology , biology , cell , chemokine , receptor , biochemistry , gene
Radiation has well-known and well-characterized direct toxic effects on cells and tissues. However, low-dose ionizing irradiation (LDIR) can also enhance the invasion and migration of tumor cells, and the mechanisms underlying these effects remain unclear. The present study aimed to investigate changes induced in the migration and invasion of A549 cells after LDIR and to explore the potential molecular mechanism.