Open Access<p>Vital and Distinct Roles of H2A.Z Isoforms in Hepatocellular Carcinoma</p>
Author(s) -
Shaomei Tang,
Xiaoliang Huang,
Xi Wang,
Xiaoting Zhou,
Huan Huang,
Liwen Qin,
Hongyu Tao,
Qiuyan Wang,
Yuting Tao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s243823
Subject(s) - gene isoform , alternative splicing , spliceosome , hepatocellular carcinoma , rna splicing , histone , liver cancer , cell growth , cancer research , downregulation and upregulation , biology , knockout mouse , cancer , gene , microbiology and biotechnology , rna , genetics
H2A.Z is an oncogenic histone variant that is overexpressed in cancers. Two isoforms of H2A.Z, H2AFZ and H2AFV, are identical except for a three-amino acid difference. However, their isoform-specific functions remain unclear in cancer development. Thereby, this study aimed to investigate whether the two isoforms play distinct functions in hepatocarcinogenesis.