Open Access<p><em>miR-602</em> Mediates the RASSF1A/JNK Pathway, Thereby Promoting Postoperative Recurrence in Nude Mice with Liver Cancer</p>
Author(s) -
Cheng Zhou,
Yajing Huang,
Yongxu Chen,
Yingjie Xie,
Huihong Wen,
Wei Tan,
Changjun Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s243651
Subject(s) - transfection , cancer research , liver cancer , hepatocellular carcinoma , medicine , cancer , mir 122 , gene , microrna , biology , biochemistry
At present, there are few studies on the mechanisms underlying postoperative recurrence of liver cancer, and the mechanism of action of miR-602 in postoperative recurrence of liver tumors is not clear. Our goals were to investigate the effects of miR-602 on the expression of the Ras-associated domain family 1A ( RASSF1A ) gene and the regulation of primary and recurrent hepatic tumors to clarify the molecular mechanisms of miR-602 in postoperative hepatocellular carcinoma.