Open Access<p>Berberine Inhibits the Apoptosis-Induced Metastasis by Suppressing the iPLA2/LOX-5/LTB4 Pathway in Hepatocellular Carcinoma</p>
Author(s) -
Yawei Zhao,
Kan He,
Huilin Zheng,
Madi Sun,
Tongfei Shi,
Xiao Zheng,
Dan Shao,
Hansi Zhang,
Fengying Guan,
Jing Li,
Li Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s243357
Subject(s) - metastasis , apoptosis , cancer research , hepatocellular carcinoma , berberine , adhesion , tumor microenvironment , cytotoxic t cell , medicine , western blot , cell adhesion , chemistry , cancer , pharmacology , in vitro , tumor cells , biochemistry , organic chemistry , gene
Hepatocellular carcinoma (HCC) is one of the most malignant cancers around the world. HCC is less sensitive to conventional cytotoxic agents and easily develops into systemic metastases. However, the molecular mechanisms of the metastasis of HCC are poorly understood and need elucidation.