Open AccessMicroRNA-374b-5p Functions as a Tumor Suppressor in Non-Small Cell Lung Cancer by Targeting FOXP1 and Predicts Prognosis of Cancer Patients
Author(s) -
Jianzhao Li,
Xinfang Zhang,
Jiaying Tang,
Cuixue Gong
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s243221
Subject(s) - lung cancer , medicine , microrna , proportional hazards model , oncology , cancer , cancer research , cell growth , downregulation and upregulation , malignancy , cell , metastasis , survival analysis , biology , gene , biochemistry , genetics
Lung cancer remains the most frequent malignancy worldwide with increasing morbidity and mortality. This study aimed to assess the expression of microRNA-374b-5p (miR-374b-5p) in tissues and cell lines of non-small cell lung cancer (NSCLC) and to evaluate the prognostic value of miR-374b-5p as well as its biological function in tumor progression.