Open Access<p>Alpha-1 Antitrypsin Induces Epithelial-to-Mesenchymal Transition, Endothelial-to-Mesenchymal Transition, and Drug Resistance in Lung Cancer Cells</p>
Author(s) -
Dongming Wu,
Teng Li,
Shihua Deng,
Rong Han,
Ting Zhang,
Jing Li,
Ying Xu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s242579
Subject(s) - epithelial–mesenchymal transition , cancer research , lung cancer , transfection , cell migration , mesenchymal stem cell , downregulation and upregulation , metastasis , gentamicin protection assay , immunohistochemistry , cell , cell culture , cancer , biology , medicine , pathology , gene , biochemistry , genetics
Alpha-1 antitrypsin (A1AT) is a secreted protein that plays an important role in various diseases. However, the role of A1AT in non-small cell lung cancer is obscure.