Open Access<p>MiR-124-3p.1 Sensitizes Ovarian Cancer Cells to Mitochondrial Apoptosis Induced by Carboplatin</p>
Author(s) -
XingWang Deng,
Yi Chen,
Zhao Liu,
Jingning Xu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s242342
Subject(s) - carboplatin , ovarian cancer , apoptosis , cancer research , transfection , microrna , protein kinase b , cancer , western blot , medicine , chemistry , cell culture , oncology , biology , cisplatin , chemotherapy , gene , biochemistry , genetics
Carboplatin is a platinum-based chemotherapeutic drug that is commonly used as a treatment for ovarian cancer. However, high doses and repeated use of carboplatin usually reduce the sensitivity of cancer cells to the drug. There is an urgent need to develop strategies to increase the sensitivity of ovarian cancer cells to carboplatin.