Open Access<p>Metformin Promotes Beclin1-Dependent Autophagy to Inhibit the Progression of Gastric Cancer</p>
Author(s) -
Su Liu,
Chao Yang,
Huanqiu Chen,
Yun Chen,
Gang Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s242298
Subject(s) - autophagy , metformin , cancer , cancer research , medicine , chemistry , oncology , apoptosis , biochemistry , insulin
Metformin is the first-line blood sugar control drug for type 2 diabetes, but recent epidemiological studies have shown that it inhibits the growth of a variety of tumours. However, few studies have examined metformin effects on gastric cancer (GC), and the anticancer mechanism has not been fully elucidated.