Open Access<p>MiR-153-5p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Paclitaxel by Inducing G2M Phase Arrest</p>
Author(s) -
Yang Wang,
Nan Wu,
Jun Zhang,
Huidong Wang,
Xiaojuan Men
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s241640
Subject(s) - cyclin dependent kinase 1 , triple negative breast cancer , cyclin b1 , paclitaxel , cancer research , skbr3 , apoptosis , viability assay , protein kinase b , downregulation and upregulation , transfection , cell cycle , chemistry , flow cytometry , microbiology and biotechnology , cancer cell , breast cancer , biology , medicine , cancer , biochemistry , human breast , gene
Paclitaxel (PTX) resistance is a main obstacle for the treatment of triple-negative breast cancers (TNBC). Evidences have shown that miR-153-5p could induce the apoptosis of breast cancer cells. Thus, this study aimed to investigate the effect of miR-153-5p on PTX-resistance TNBC cells.