Open Access<p>The KN Motif and Ankyrin Repeat Domains 1/CXXC Finger Protein 5 Axis Regulates Epithelial-Mesenchymal Transformation, Metastasis and Apoptosis of Gastric Cancer via Wnt Signaling</p>
Author(s) -
Xin Chen,
Xiaodong Wang,
Lanjuan Yi,
Ying Song
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s240991
Subject(s) - wnt signaling pathway , apoptosis , axin2 , epithelial–mesenchymal transition , cancer research , catenin , chemistry , western blot , signal transduction , downregulation and upregulation , microbiology and biotechnology , biology , biochemistry , gene
Emerging research indicates that CXXC finger protein 5 (CXXC5) is involved in the development of various cancers. Besides, KN motif and ankyrin repeat domains 1 (KANK1) was proved as a tumor suppressor in multiple cancers. Our study aimed to illustrate the functional role and mechanism of CXXC5 and KANK1 in gastric cancer (GC) pathogenesis.