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The cancer-testis antigen, which is a preferentially expressed antigen of melanoma (PRAME), is an ideal target for immunotherapy and cancer vaccines. Since the expression of this antigen is relevant to therapy responses, the heterogeneity in its expression and the underlying mechanism need to be investigated.

<p>Both Methylation and Copy Number Variation Participated in the Varied Expression of PRAME in Multiple Myeloma</p>