Open Access<p>Both Methylation and Copy Number Variation Participated in the Varied Expression of PRAME in Multiple Myeloma</p>
Author(s) -
Lu Yang,
FengTing Dao,
Yan Chang,
Yazhe Wang,
Ling-Di Li,
Wen Ming Chen,
Ling-Yu Long,
Yanrong Liu,
Kai-Yan Liu,
YaZhen Qin
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s240979
Subject(s) - methylation , cpg site , exon , microbiology and biotechnology , dna methylation , antigen , bisulfite sequencing , cancer research , multiple myeloma , biology , medicine , gene , immunology , gene expression , genetics
The cancer-testis antigen, which is a preferentially expressed antigen of melanoma (PRAME), is an ideal target for immunotherapy and cancer vaccines. Since the expression of this antigen is relevant to therapy responses, the heterogeneity in its expression and the underlying mechanism need to be investigated.