Open Access<p>Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells</p>
Author(s) -
Zhirui Zeng,
Jinzhi Lan,
Shan Lei,
Yuan Yang,
Zhiwei He,
Yan Xue,
Tengxiang Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s240535
Subject(s) - pkm2 , ornithine decarboxylase , cancer research , cell growth , chemistry , gene knockdown , apoptosis , flow cytometry , protein kinase b , pyruvate kinase , microbiology and biotechnology , biology , glycolysis , biochemistry , enzyme
Previously, we showed that lactate promoted the proliferation and mobility of hepatocellular carcinoma (HCC) cells by increasing the expression of ornithine decarboxylase 1 (ODC1). In this study, we determined the relationship between ODC1 and pyruvate kinase M2 (PKM2, a key lactate metabolism enzyme), and determined the combined effects of difluoromethylornithine (DFMO; an ODC1 inhibitor) and compound 3k (a PKM2 inhibitor) on HCC cells.