Open Access<p>Antitumor Actions of Intratumoral Delivery of Membrane-Fused Mitochondria in a Mouse Model of Triple-Negative Breast Cancers</p>
Author(s) -
Jui-Chih Chang,
Huei-Shin Chang,
Yu-Shiang Wu,
Wen-Ling Cheng,
Ta-Tsung Lin,
Hui-Ju Chang,
ShouTung Chen,
ChinSan Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s238143
Subject(s) - mitochondrion , apoptosis , breast cancer , cancer research , angiogenesis , in vivo , pathology , medicine , oxidative stress , chemistry , cancer , biology , biochemistry , microbiology and biotechnology
The transfer of whole mitochondria has been demonstrated to be beneficial for treating breast cancer because it induces apoptosis and drug sensitivity; however, in vivo evidence of this benefit remains scant. The present study compared the transplantation of mitochondria with instinctive (Mito) and membrane-fused morphologies induced by Pep-1 conjugation (P-Mito) using a mouse model of triple-negative breast cancers.