Open Access<p>Simvastatin Inhibits the Malignant Behaviors of Gastric Cancer Cells by Simultaneously Suppressing YAP and β-Catenin Signaling</p>
Author(s) -
Qing Liu,
HongWei Xiao,
Sheng Zhou,
Qiulin Tang,
Jitao Zhou,
Min Ren,
Feng Bi
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s237693
Subject(s) - simvastatin , cancer , cancer research , catenin , cancer cell , rhoa , apoptosis , signal transduction , medicine , statin , chemistry , pharmacology , wnt signaling pathway , biochemistry
Statins, which are used to lower blood cholesterol levels by inhibiting HMG-CoA reductase, have shown anticancer effects in many cancer cells. However, the role of statins in gastric cancer remains unclear. This study aims to investigate whether the statins could antagonize progression of gastric cancer cells and tried to find the molecule mechanism.