Open Access<p>Knockdown of lncRNA <em>PCAT6</em> Enhances Radiosensitivity in Triple-Negative Breast Cancer Cells by Regulating<em> miR-185-5p</em>/<em>TPD52</em> Axis</p>
Author(s) -
Rui Shi,
Peng Wu,
Miaomiao Liu,
Bing Chen,
Longjiao Cong
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s237559
Subject(s) - radiosensitivity , gene knockdown , cancer research , microrna , biology , triple negative breast cancer , apoptosis , cancer , breast cancer , medicine , gene , genetics , radiation therapy
Long non-coding RNAs (lncRNAs) have been reported to play essential roles in regulating the radiosensitivity of cancers. Prostate cancer-associated transcript 6 ( PCAT6 ) exerts oncogenic roles in several tumors. However, the roles of PCAT6 and its underlying mechanism in regulating the radiosensitivity of triple-negative breast cancer (TNBC) have not been investigated.