Open Access<p>Diosgenin and GSK126 Produce Synergistic Effects on Epithelial–Mesenchymal Transition in Gastric Cancer Cells by Mediating EZH2 via the Rho/ROCK Signaling Pathway</p>
Author(s) -
Shanshan Liu,
Guihong Rong,
Xia Li,
Lijun Geng,
ZhiNeng Zeng,
Dong-xiang Jiang,
Jun Yang,
YeSheng Wei
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s237474
Subject(s) - diosgenin , apoptosis , cell cycle , chemistry , cell , flow cytometry , cancer research , microbiology and biotechnology , medicine , biology , biochemistry , organic chemistry
Diosgenin, a natural steroidal saponin isolated from Trigonella foenum-graecum , has been reported to exert anti-cancer effects. Inhibitors of enhancer of zeste homology 2 (EZH2) have been widely used in treatment of cancers. However, the effects of combined treatment with diosgenin and an EZH2 inhibitor on gastric cancer (GC) cells, and the mechanism for those effects are not fully understood.