Open Access<p>TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition</p>
Author(s) -
Yangyang Xiao,
Jilin Qing,
Baoxuan Li,
Liuyan Chen,
g Sheng-zhou,
Wenhui Yang,
Xiaogang Tang,
Zhizhong Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s237222
Subject(s) - nasopharyngeal carcinoma , epithelial–mesenchymal transition , vimentin , cancer research , metastasis , mmp2 , mesenchymal stem cell , cell migration , biology , flow cytometry , downregulation and upregulation , cell growth , pathology , immunohistochemistry , cell , cancer , immunology , medicine , radiation therapy , biochemistry , gene , genetics
T-cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) was originally found to negatively regulate immune response and mediate immune escape in tumors. Subsequently, an increasing body of evidence has shown that TIM-3 exerts positive functions in the development and progression of several tumors. However, the role of TIM-3 in nasopharyngeal carcinoma (NPC) remains unknown.